One of the first things we’re told as expecting mums is just how important folic acid is in pregnancy, to helps protect babies from neural tube defects like spina bifida. But new research out of South Australia suggests that too much might not be such a good thing either.
A study from Flinders University and the University of Adelaide has found a link between high folic acid intake and a greater risk of gestational diabetes. And with rates of gestational diabetes in Australia more than tripling over the past decade, it’s raising some big questions about current supplement guidelines.
Researchers say the problem comes from a double dose effect. Folic acid is added to many foods as part of national fortification programs, and on top of that, many pregnant women are taking higher-than-recommended supplements.
Dr Tanja Jankovic-Karasoulos, who led the study of more than 2000 women, said their findings show that, “excess maternal folate significantly increases gestational diabetes risk” in today’s pregnancy population. She suspects that rising folic acid intake over the past 10–15 years could be part of the reason gestational diabetes is becoming so common.
“Our study suggests that higher-than-recommended FA intake may have unintended consequences for pregnancy,” she explained.
“The placenta is central to regulating maternal glucose tolerance in pregnancy, so we need to understand how high FA intake affects placental function and, in turn, insulin resistance and gestational diabetes risk.”
The researchers say the findings highlight an urgent need to establish a safe upper limit for folic acid intake during pregnancy, as well as improve guidelines on folic acid supplementation during pregnancy.






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